Thursday, December 12, 2013

Cranberries and Cancer

I started adding cranberries to my smoothie a month or so ago when I started seeing them fresh at Whole Foods. After reading this article, I've decided to put them in my smoothie everyday. Frozen cranberries are available year round and there doesn't appear to be any difference in the nutritional value of fresh and frozen. They are rather tart but I've found that if I add an apple the smoothie tastes sweet enough. I also add kale, spinach and a carrot. Rosie knows when I'm making my smoothies and has gotten used to having a piece of carrot and apple.

Which Common Fruits Fight Cancer Better?
by Michael Gregor, MD

Recently, researchers compared the ability of eleven common fruits to suppress cancer cell growth in vitro. Which do you think was most effective—apples, bananas, cranberries, grapefruits, grapes, lemons, oranges, peaches, pears, pineapples, or strawberries?

There are many ways to compare the healthfulness of different foods. For example, if you were interested in antioxidants you might compare vitamin C content. If you compared vitamin C content between our two most popular fruits, apples and bananas, then bananas would appear twice as healthy (10 mg in a banana compared to only 5mg in an apple). But vitamin C is just one of thousands of different phytonutrients in fruits and vegetables. It turns out the vitamin C in apples accounts for less than 1 percent of an apple’s total antioxidant activity.

In my 5-min video Which Fruit Fights Cancer Better? I show a graph of the total antioxidant content of a red delicious apple. The amount contributed to the vitamin C is so tiny you can hardly see it. Even though there are only about 5mg of vitamin C in a small apple, it has the antioxidant equivalent of 1500 mg of vitamin C! I’ve reviewed before how taking that much vitamin C straight in a supplement may actually have a pro-oxidant effect and cause DNA damage (in my video Preventing Exercise-Induced Oxidative Stress With Watercress), but you can get three times that antioxidant power eating an apple, without the adverse effects.

Of course there’s more than just vitamin C in bananas too. I was surprised to see a study out of Harvard suggesting that bananas were a significant source of anthocyanins, the red/blue/violet phytonutrients found in berries. Maybe I underestimated bananas? They are, after all, technically berries.

Anthocyanins have been found in blue, purple, orange-red, red-purple, and pink-purple wild bananas, but none in domesticated yellow. In the Harvard researchers’ defense, they just took values from the USDA, and it turns out USDA apparently made a mistake. There are no anthocyanins in store-bought bananas, and despite twice the vitamin C, bananas are beat out by apples in terms of overall antioxidant power. But that’s just measuring the ability of these fruits to quench an oxidation reaction in a test tube. It would be nice to measure actual biological activity.

In the red delicious apple study, researchers also measured the ability of apple extracts, from both peeled and unpeeled apples, to suppress the growth of human cancer cells growing in a petri dish compared to control. Wouldn’t it be great to be able to compare that kind of superpower between different fruits? Well, now we can!

In my video Which Fruit Fights Cancer Better? I show a graph of cancer cell proliferation versus increasing concentrations of the 11 most common fruits eaten in the United States. If you drip water on these cancer cells as a control, nothing happens. They start out powering away at 100 percent growth and they keep powering away at 100 percent growth. And pineapples, pears, and oranges don’t do much better.

Peaches start pulling away from the pack. At high peach concentrations, cancer cell proliferation drops about 10 percent, but bananas and grapefruits appear to work four times better, dropping cancer growth rates by about 40 percent. Red grapes, strawberries and apples do even better, cutting cancer cell growth up to half at only half the dose, but the two fruits that won, causing a dramatic drop in cancer proliferation at just tiny doses, were lemons and cranberries. So if you look at the effective dose required to suppress liver cancer cell proliferation, apples are more powerful than bananas, but cranberries win the day. And there was no effective dose listed for orange, pear, and pineapple since they didn’t appear to affect the cancer cell growth at all.

Dr. Gregor's website is

No comments: